Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade

Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade

Background CD8+ tissue-resident memory T (TRM) cells, marked by CD103 (ITGAE) expression, are thought to actively suppress cancer progression, leading to the hypothesis that their presence in tumors may predict response to immunotherapy.Methods Here, we test this by combining high-dimensional single...

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Bibliographic Details
Main Authors: Marcin Kowanetz, Thomas Powles, Hartmut Koeppen, Jane Grogan, Patrick Caplazi, Ira Mellman, Wei Zou, Sanjeev Mariathasan, Priti S. Hegde, Mark McCleland, Jacqueline McBride, Zora Modrusan, Romain Banchereau, Avantika S. Chitre, Alexis Scherl, Thomas D. Wu, Namrata S. Patil, Patricia de Almeida, Edward E. Kadel, III, Shravan Madireddi, Amelia Au-Yeung, Chikara Takahashi, Ying-Jiun Chen, Rhea Nersesian, Ehab A. El-Gabry, Mark D. Robida, Jeffrey C. Hung, Shadi Toghi Eshgi, W. Rodney Mathews, William E O'Gorman
Format: Article
Language:English
Published: BMJ Publishing Group 2021-04-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/9/4/e002231.full

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https://jitc.bmj.com/content/9/4/e002231.full

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