Proteomic analysis of holocarboxylase synthetase deficient-MDA-MB-231 breast cancer cells revealed the biochemical changes associated with cell death, impaired growth signaling, and metabolism

Proteomic analysis of holocarboxylase synthetase deficient-MDA-MB-231 breast cancer cells revealed the biochemical changes associated with cell death, impaired growth signaling, and metabolism

We have previously shown that the holocarboxylase synthetase (HLCS) is overexpressed in breast cancer tissue of patients, and silencing of its expression in triple-negative cancer cell line inhibits growth and migration. Here we investigated the global biochemical changes associated with HLCS knockd...

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Bibliographic Details
Main Authors: Witchuda Sukjoi, Clifford Young, Mitchell Acland, Siraprapa Siritutsoontorn, Sittiruk Roytrakul, Manuela Klingler-Hoffmann, Peter Hoffmann, Sarawut Jitrapakdee
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Molecular Biosciences
Subjects:
holocarboxylase synthetase
biotin carboxylases
breast cancer
proteomics
metabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1250423/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2023.1250423/full

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