In vivo evaluation of two thiazolidin-4-one derivatives in high sucrose diet fed pre-diabetic mice and their modulatory effect on AMPK, Akt and p38 MAP kinase in L6 cells

In vivo evaluation of two thiazolidin-4-one derivatives in high sucrose diet fed pre-diabetic mice and their modulatory effect on AMPK, Akt and p38 MAP kinase in L6 cells

We had previously demonstrated the anti-diabetic potential and pancreatic protection of two thiazolidin-4-one derivatives containing nicotinamide moiety (NAT-1 and NAT-2) in STZ-induced diabetic mice. However, due to the limitations of the STZ model, we decided to undertake a detailed evaluation of...

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Bibliographic Details
Main Authors: Jayesh Mudgal, Priya Shetty, Neetinkumar D Reddy, Akhila H.S., Karthik Gourishetti, Geetha Mathew, Pawan Ganesh Nayak, Nitesh Kumar, Anoop Kishore, Nampurath Gopalan Kutty, Krishnadas Nandakumar, Rekha Raghuveer Shenoy, Chamallamudi Mallikarjuna Rao, Alex Joseph
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Pharmacology
Subjects:
Akt
AMPK
mouse model
p38 MAPK
High sucrose diet
thiazolidin-4-one derivatives
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00381/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00381/full

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