Specific RNA structures in the 5′ untranslated region of the human cytomegalovirus major immediate early transcript are critical for efficient virus replication

Specific RNA structures in the 5′ untranslated region of the human cytomegalovirus major immediate early transcript are critical for efficient virus replication

ABSTRACTHuman cytomegalovirus (HCMV) requires the robust expression of two immediate early proteins, IE1 and IE2, immediately upon infection to suppress the antiviral response and promote viral gene expression. While transcriptional control of IE1 and IE2 has been extensively studied, the role of po...

Full description

Bibliographic Details
Main Authors: Bekah Dickmander, Andrew Hale, Wes Sanders, Erik Lenarcic, Ben Ziehr, Nathaniel J. Moorman
Format: Article
Language:English
Published: American Society for Microbiology 2024-02-01
Series:mBio
Subjects:
human herpesvirus
human cytomegalovirus
HCMV
mRNA translation
protein synthesis
major immediate early gene
Online Access:https://journals.asm.org/doi/10.1128/mbio.02621-23

Internet

https://journals.asm.org/doi/10.1128/mbio.02621-23

Similar Items