Current advances in understanding the molecular profile of hereditary diffuse gastric cancer and its clinical implications

Abstract Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer syndrome attributed to germline CDH1 mutations that carries a high risk for early onset DGC. HDGC raises a significant health issue due to its high penetrance and mortality unless diagnosed early. The definitive treatm...

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Bibliographic Details
Main Authors: Hui Jun Lim, Lizhe Zhuang, Rebecca C. Fitzgerald
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Online Access:https://doi.org/10.1186/s13046-023-02622-3