Agent-based modeling of the prostate tumor microenvironment uncovers spatial tumor growth constraints and immunomodulatory properties

Agent-based modeling of the prostate tumor microenvironment uncovers spatial tumor growth constraints and immunomodulatory properties

Abstract Inhibiting androgen receptor (AR) signaling through androgen deprivation therapy (ADT) reduces prostate cancer (PCa) growth in virtually all patients, but response may be temporary, in which case resistance develops, ultimately leading to lethal castration-resistant prostate cancer (CRPC)....

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Bibliographic Details
Main Authors: Maisa N. G. van Genderen, Jeroen Kneppers, Anniek Zaalberg, Elise M. Bekers, Andries M. Bergman, Wilbert Zwart, Federica Eduati
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:npj Systems Biology and Applications
Online Access:https://doi.org/10.1038/s41540-024-00344-6

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https://doi.org/10.1038/s41540-024-00344-6

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