Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology

Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology

ABSTRACTMalaria elimination efforts in Southeast Asia have been hindered by multidrug-resistant Plasmodium falciparum. High-grade resistance to piperaquine (PPQ, used in combination with dihydroartemisinin) is associated with PfCRT mutations that arose in strains expressing the PfCRT Dd2 isoform, wh...

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Bibliographic Details
Main Authors: Laura M. Hagenah, Satish K. Dhingra, Jennifer L. Small-Saunders, Tarrick Qahash, Andreas Willems, Kyra A. Schindler, Gabriel W. Rangel, Eva Gil-Iturbe, Jonathan Kim, Emiliya Akhundova, Tomas Yeo, John Okombo, Filippo Mancia, Matthias Quick, Paul D. Roepe, Manuel Llinás, David A. Fidock
Format: Article
Language:English
Published: American Society for Microbiology 2024-01-01
Series:mBio
Subjects:
Plasmodium falciparum
malaria
drug resistance evolution
fitness
PfCRT
Online Access:https://journals.asm.org/doi/10.1128/mbio.01832-23

Internet

https://journals.asm.org/doi/10.1128/mbio.01832-23

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