Cigarette smoke extract-mediated FABP4 upregulation suppresses viability and induces apoptosis, inflammation and oxidative stress of bronchial epithelial cells by activating p38 MAPK/MK2 signaling pathway

Cigarette smoke extract-mediated FABP4 upregulation suppresses viability and induces apoptosis, inflammation and oxidative stress of bronchial epithelial cells by activating p38 MAPK/MK2 signaling pathway

Abstract Background Long-term inhalation of cigarette smoke is considered to be one of the main causes of bronchial epithelioid cell damage, but its underlying mechanism has to be further clarified. Methods Gene expression at mRNA level and protein levels were detected by qRT-PCR and western blot an...

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Bibliographic Details
Main Authors: Wei Zhang, Yibin Zhang, Qi Zhu
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Journal of Inflammation
Subjects:
Cigarette smoke extract
Bronchial inflammation
Fatty acid binding protein 4
p38 MAPK/MK2 signaling pathway
Inflammatory response
Cell apoptosis
Online Access:https://doi.org/10.1186/s12950-022-00304-z

Internet

https://doi.org/10.1186/s12950-022-00304-z

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