Nicotinamide Mononucleotide Supplementation Improves Mitochondrial Dysfunction and Rescues Cellular Senescence by NAD<sup>+</sup>/Sirt3 Pathway in Mesenchymal Stem Cells

Nicotinamide Mononucleotide Supplementation Improves Mitochondrial Dysfunction and Rescues Cellular Senescence by NAD<sup>+</sup>/Sirt3 Pathway in Mesenchymal Stem Cells

In vitro expansion-mediated replicative senescence has severely limited the clinical applications of mesenchymal stem cells (MSCs). Accumulating studies manifested that nicotinamide adenine dinucleotide (NAD<sup>+</sup>) depletion is closely related to stem cell senescence and mitochondr...

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Bibliographic Details
Main Authors: Huan Wang, Yanan Sun, Chenchen Pi, Xiao Yu, Xingyu Gao, Chang Zhang, Hui Sun, Haiying Zhang, Yingai Shi, Xu He
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
MSC senescence
NMN
NAD<sup>+</sup>
Sirt3
mitochondrial function
Online Access:https://www.mdpi.com/1422-0067/23/23/14739

Internet

https://www.mdpi.com/1422-0067/23/23/14739

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