Metabolomics-based phenotypic screens for evaluation of drug synergy via direct-infusion mass spectrometry

Metabolomics-based phenotypic screens for evaluation of drug synergy via direct-infusion mass spectrometry

Summary: Drugs used in combination can synergize to increase efficacy, decrease toxicity, and prevent drug resistance. While conventional high-throughput screens that rely on univariate data are incredibly valuable to identify promising drug candidates, phenotypic screening methodologies could be be...

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Bibliographic Details
Main Authors: Xiyuan Lu, G. Lavender Hackman, Achinto Saha, Atul Singh Rathore, Meghan Collins, Chelsea Friedman, S. Stephen Yi, Fumio Matsuda, John DiGiovanni, Alessia Lodi, Stefano Tiziani
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:iScience
Subjects:
bioinformatics
metabolomics
omics
pharmacoinformatics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222004916

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http://www.sciencedirect.com/science/article/pii/S2589004222004916

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