Peroxisome Proliferator-Activated Receptor γ (PPARγ ) Suppresses Colonic Epithelial Cell Turnover and Colon Carcinogenesis Through Inhibition of the β-Catenin / T Cell Factor (TCF) Pathway

Peroxisome Proliferator-Activated Receptor γ (PPARγ ) Suppresses Colonic Epithelial Cell Turnover and Colon Carcinogenesis Through Inhibition of the β-Catenin / T Cell Factor (TCF) Pathway

Peroxisome proliferator-activated receptor γ (PPARγ ), a nuclear receptor superfamily member, plays a major role in lipid metabolism and insulin sensitivity. We investigated the role of PPARγ in colonic epithelial cell turnover and carcinogenesis in colon because PPARγ is strongly expressed in colon...

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Main Authors: Toshio Fujisawa, Atsushi Nakajima, Nobutaka Fujisawa, Hirokazu Takahashi, Ikuko Ikeda, Ayako Tomimoto, Kyoko Yonemitsu, Noriko Nakajima, Chiho Kudo, Koichiro Wada, Naoto Kubota, Yasuo Terauchi, Takashi Kadowaki, Hitoshi Nakagama, Richard S. Blumberg
Format: Article
Language:English
Published: Elsevier 2008-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319314835

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http://www.sciencedirect.com/science/article/pii/S1347861319314835

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