Deconvolution of the hematopoietic stem cell microenvironment reveals a high degree of specialization and conservation

Deconvolution of the hematopoietic stem cell microenvironment reveals a high degree of specialization and conservation

Summary: Understanding the regulation of normal and malignant human hematopoiesis requires comprehensive cell atlas of the hematopoietic stem cell (HSC) regulatory microenvironment. Here, we develop a tailored bioinformatic pipeline to integrate public and proprietary single-cell RNA sequencing (scR...

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Bibliographic Details
Main Authors: Jin Ye, Isabel A. Calvo, Itziar Cenzano, Amaia Vilas, Xabier Martinez-de-Morentin, Miren Lasaga, Diego Alignani, Bruno Paiva, Ana C. Viñado, Patxi San Martin-Uriz, Juan P. Romero, Delia Quilez Agreda, Marta Miñana Barrios, Ignacio Sancho-González, Gabriele Todisco, Luca Malcovati, Nuria Planell, Borja Saez, Jesper N. Tegner, Felipe Prosper, David Gomez-Cabrero
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:iScience
Subjects:
Biological sciences
Stem cells research
Omics
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222004953

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http://www.sciencedirect.com/science/article/pii/S2589004222004953

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