The Effect of the Ala16Val Mutation on the Secondary Structure of the Manganese Superoxide Dismutase Mitochondrial Targeting Sequence

The Effect of the Ala16Val Mutation on the Secondary Structure of the Manganese Superoxide Dismutase Mitochondrial Targeting Sequence

Manganese Superoxide Dismutase (MnSOD) represents a mitochondrial protein that scavenges reactive oxygen species (ROS) responsible for oxidative stress. A known single nucleotide polymorphism (SNP) rs4880 on the SOD2 gene, causing a mutation from alanine to valine (Ala16Val) in the primary structure...

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Bibliographic Details
Main Authors: Matic Broz, Veronika Furlan, Samo Lešnik, Marko Jukič, Urban Bren
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Antioxidants
Subjects:
manganese superoxide dismutase
polymorphism rs4880
mutation Ala16Val
molecular dynamics simulations
oxidative stress
Online Access:https://www.mdpi.com/2076-3921/11/12/2348

Internet

https://www.mdpi.com/2076-3921/11/12/2348

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