Targeted Long-Read Bisulfite Sequencing Identifies Differences in the <i>TERT</i> Promoter Methylation Profiles between <i>TERT</i> Wild-Type and <i>TERT</i> Mutant Cancer Cells

Targeted Long-Read Bisulfite Sequencing Identifies Differences in the <i>TERT</i> Promoter Methylation Profiles between <i>TERT</i> Wild-Type and <i>TERT</i> Mutant Cancer Cells

Background: <i>TERT</i> promoter methylation, located several hundred base pairs upstream of the transcriptional start site, is cancer specific and correlates with increased TERT mRNA expression and poorer patient outcome. Promoter methylation, however, is not mutually exclusive to <i...

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Bibliographic Details
Main Authors: Seungjae Lee, Ti-Cheng Chang, Patrick Schreiner, Yiping Fan, Neeraj Agarwal, Charles Owens, Reinhard Dummer, John M. Kirkwood, Raymond L. Barnhill, Dan Theodorescu, Gang Wu, Armita Bahrami
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cancers
Subjects:
<i>TERT</i> promoter
methylation
bisulfite sequencing
allele-specific methylation
proximal and distal promoters
Online Access:https://www.mdpi.com/2072-6694/14/16/4018

Internet

https://www.mdpi.com/2072-6694/14/16/4018

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