Reactive oxygen species (ROS)-response nanomedicine through knocking down a novel therapeutic target NEDD8-conjugating enzyme UBC12 (UBE2M) in the treatment of liver cancer

Reactive oxygen species (ROS)-response nanomedicine through knocking down a novel therapeutic target NEDD8-conjugating enzyme UBC12 (UBE2M) in the treatment of liver cancer

Knocking down the UBC12 with siRNA could significantly suppress the Neddylation pathway and result in an admirable anti-cancer effect. However, how to transport siRNA in vivo with low potential toxicity is an urgent problem to be solved. For enhancing bioavailability of siRNA, folic acid (FA)-modifi...

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Bibliographic Details
Main Authors: Zhanxia Zhang, Yongqing Heng, Wei Cheng, Yongfu Pan, Shuaishuai Ni, Hegen Li
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Materials & Design
Subjects:
UBC12
Neddylation
siRNA-loaded nanomedicine
Smart response
Targeted delivery
Online Access:http://www.sciencedirect.com/science/article/pii/S026412752100201X

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http://www.sciencedirect.com/science/article/pii/S026412752100201X

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