Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects

Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects

In recent years, accumulating evidence has shown that the innate immune complement system is involved in several aspects of normal brain development and in neurodevelopmental disorders, including autism spectrum disorder (ASD). Although abnormal expression of complement components was observed in po...

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Bibliographic Details
Main Authors: Fernanda Mansur, André Luiz Teles e Silva, Ana Karolyne Santos Gomes, Juliana Magdalon, Janaina Sena de Souza, Karina Griesi-Oliveira, Maria Rita Passos-Bueno, Andréa Laurato Sertié
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
complement system
autism spectrum disorder
iPSC-derived astrocytes
complement C4
synaptic pruning
Online Access:https://www.mdpi.com/1422-0067/22/14/7579

Internet

https://www.mdpi.com/1422-0067/22/14/7579

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