Partial proteasomal degradation of Lola triggers the male-to-female switch of a dimorphic courtship circuit

It is unclear how some Drosophila neurons develop sex-specific neurites that contribute to dimorphic circuitries required for gendered behavior. The authors show that sex-specific cleavage by the E3 ubiquitin ligase Cullin1 and 26S proteasome of the pleiotropic BTB-ZF transcription factor Lola confe...

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Bibliographic Details
Main Authors: Kosei Sato, Hiroki Ito, Atsushi Yokoyama, Gakuta Toba, Daisuke Yamamoto
Format: Article
Language:English
Published: Nature Portfolio 2019-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-08146-1