Cis-regulatory CYP6P9b P450 variants associated with loss of insecticide-treated bed net efficacy against Anopheles funestus
Bed nets treated with insecticides have been instrumental in reducing malaria mortality, but insecticide resistance is on the rise. Here, Mugenzi et al. identify genetic variants in the P450 gene CYP6P9b of Anopheles funestus that associate with insecticide resistance and develop a PCR-based diagnos...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-12686-5 |
| _version_ | 1818342125132054528 |
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| author | Leon M. J. Mugenzi Benjamin D. Menze Magellan Tchouakui Murielle J. Wondji Helen Irving Micareme Tchoupo Jack Hearn Gareth D. Weedall Jacob M. Riveron Charles S. Wondji |
| author_facet | Leon M. J. Mugenzi Benjamin D. Menze Magellan Tchouakui Murielle J. Wondji Helen Irving Micareme Tchoupo Jack Hearn Gareth D. Weedall Jacob M. Riveron Charles S. Wondji |
| author_sort | Leon M. J. Mugenzi |
| collection | DOAJ |
| description | Bed nets treated with insecticides have been instrumental in reducing malaria mortality, but insecticide resistance is on the rise. Here, Mugenzi et al. identify genetic variants in the P450 gene CYP6P9b of Anopheles funestus that associate with insecticide resistance and develop a PCR-based diagnostic assay to help identify pyrethroid-resistant strains. |
| first_indexed | 2024-12-13T16:09:43Z |
| format | Article |
| id | doaj.art-ccf4a881a06c4c60933c5e58ed594e6b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:09:43Z |
| publishDate | 2019-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ccf4a881a06c4c60933c5e58ed594e6b2022-12-21T23:38:59ZengNature PortfolioNature Communications2041-17232019-10-0110111110.1038/s41467-019-12686-5Cis-regulatory CYP6P9b P450 variants associated with loss of insecticide-treated bed net efficacy against Anopheles funestusLeon M. J. Mugenzi0Benjamin D. Menze1Magellan Tchouakui2Murielle J. Wondji3Helen Irving4Micareme Tchoupo5Jack Hearn6Gareth D. Weedall7Jacob M. Riveron8Charles S. Wondji9Vector Biology Department, Liverpool School of Tropical MedicineVector Biology Department, Liverpool School of Tropical MedicineCentre for Research in Infectious Diseases (CRID)Vector Biology Department, Liverpool School of Tropical MedicineVector Biology Department, Liverpool School of Tropical MedicineCentre for Research in Infectious Diseases (CRID)Vector Biology Department, Liverpool School of Tropical MedicineVector Biology Department, Liverpool School of Tropical MedicineVector Biology Department, Liverpool School of Tropical MedicineVector Biology Department, Liverpool School of Tropical MedicineBed nets treated with insecticides have been instrumental in reducing malaria mortality, but insecticide resistance is on the rise. Here, Mugenzi et al. identify genetic variants in the P450 gene CYP6P9b of Anopheles funestus that associate with insecticide resistance and develop a PCR-based diagnostic assay to help identify pyrethroid-resistant strains.https://doi.org/10.1038/s41467-019-12686-5 |
| spellingShingle | Leon M. J. Mugenzi Benjamin D. Menze Magellan Tchouakui Murielle J. Wondji Helen Irving Micareme Tchoupo Jack Hearn Gareth D. Weedall Jacob M. Riveron Charles S. Wondji Cis-regulatory CYP6P9b P450 variants associated with loss of insecticide-treated bed net efficacy against Anopheles funestus Nature Communications |
| title | Cis-regulatory CYP6P9b P450 variants associated with loss of insecticide-treated bed net efficacy against Anopheles funestus |
| title_full | Cis-regulatory CYP6P9b P450 variants associated with loss of insecticide-treated bed net efficacy against Anopheles funestus |
| title_fullStr | Cis-regulatory CYP6P9b P450 variants associated with loss of insecticide-treated bed net efficacy against Anopheles funestus |
| title_full_unstemmed | Cis-regulatory CYP6P9b P450 variants associated with loss of insecticide-treated bed net efficacy against Anopheles funestus |
| title_short | Cis-regulatory CYP6P9b P450 variants associated with loss of insecticide-treated bed net efficacy against Anopheles funestus |
| title_sort | cis regulatory cyp6p9b p450 variants associated with loss of insecticide treated bed net efficacy against anopheles funestus |
| url | https://doi.org/10.1038/s41467-019-12686-5 |
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