IRG1/itaconate increases IL-10 release to alleviate mechanical and thermal hypersensitivity in mice after nerve injury

IRG1/itaconate increases IL-10 release to alleviate mechanical and thermal hypersensitivity in mice after nerve injury

Inflammation plays an important role in the occurrence and development of neuropathic pain. Immune-responsive gene 1 (IRG1) decarboxylates cis-aconitate to produce itaconate in the mitochondria. Itaconate serves as an immunomodulator of macrophages and represses inflammation in infectious diseases....

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Bibliographic Details
Main Authors: Qingyu Sun, Tingting Hu, Yurui Zhang, Xiaotong Wang, Jing Liu, Wen Chen, Chao Wei, Dianxin Liu, Weihua Wu, Ting Lan, Yumeng Ding, Zhaoli Luo, Meng Liu, Danmin Shen, Zhongnan Xiao, Liye Hu, Miaoyi Pang, Yiran Ma, Lei Shi, Peipei Wang, Jiannan Zhang, Qian Li, Fei Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
itaconate
interleukin-10
neuropathic pain
tricarboxylic acid cycle
IRG1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1012442/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.1012442/full

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