Subtleties in Clathrin heavy chain binding boxes provide selectivity among adaptor proteins of budding yeast

Abstract Clathrin forms a triskelion, or three-legged, network that regulates cellular processes by facilitating cargo internalization and trafficking in eukaryotes. Its N-terminal domain is crucial for interacting with adaptor proteins, which link clathrin to the membrane and engage with specific c...

Full description

Bibliographic Details
Main Authors: Lucas A. Defelipe, Katharina Veith, Osvaldo Burastero, Tatiana Kupriianova, Isabel Bento, Michal Skruzny, Knut Kölbel, Charlotte Uetrecht, Roland Thuenauer, Maria M. García-Alai
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54037-z