Development and Use of an Endpoint Titration Assay To Characterize Mumps IgG Avidity following Measles, Mumps, and Rubella Vaccination and Wild-Type Mumps Infection

Development and Use of an Endpoint Titration Assay To Characterize Mumps IgG Avidity following Measles, Mumps, and Rubella Vaccination and Wild-Type Mumps Infection

ABSTRACT Waning mumps IgG antibody and incomplete IgG avidity maturation may increase susceptibility to mumps virus infection in some vaccinees. To measure mumps IgG avidity, serum specimens serially diluted to the endpoint were incubated on a commercial mumps-specific IgG enzyme immunoassay and tre...

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Bibliographic Details
Main Authors: Sara Mercader, Marcia McGrew, Sun B. Sowers, Nobia J. Williams, William J. Bellini, Carole J. Hickman
Format: Article
Language:English
Published: American Society for Microbiology 2018-10-01
Series:mSphere
Subjects:
IgG immunoglobulin
avidity immunoassay
measles-mumps-rubella vaccine
mumps
vaccine failure
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00320-18

Internet

https://journals.asm.org/doi/10.1128/mSphere.00320-18

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