Altering endoplasmic reticulum stress in a model of blast-induced traumatic brain injury controls cellular fate and ameliorates neuropsychiatric symptoms

Altering endoplasmic reticulum stress in a model of blast-induced traumatic brain injury controls cellular fate and ameliorates neuropsychiatric symptoms

Neuronal injury following blast-induced traumatic brain injury (bTBI) increases the risk for neuropsychiatric disorders, yet the pathophysiology remains poorly understood. Blood-brain-barrier (BBB) disruption, endoplasmic reticulum (ER) stress, and apoptosis have all been implicated in bTBI. Microve...

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Bibliographic Details
Main Authors: Aric Flint Logsdon, Ryan Coddington Turner, Brandon Peter Lucke-Wold, Matthew James Robson, Zachary James Naser, Kelly Elizabeth Smith, Rae Reiko Matsumoto, Jason Delwyn Huber, Charles Lee Rosen
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Apoptosis
Blood-Brain Barrier
Endoplasmic Reticulum Stress
Prefrontal Cortex
Blast-Induced Traumatic Brain Injury
Salubrinal
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00421/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00421/full

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