Anticancer potential of novel 5-Fluorouracil co-crystals against MCF7 breast and SW480 colon cancer cell lines along with docking studies

Anticancer potential of novel 5-Fluorouracil co-crystals against MCF7 breast and SW480 colon cancer cell lines along with docking studies

In the present investigation, 5-Fluorouracil co-crystals with four cyclic dimers of amino acids (Glycine, Tryptophane, Leucine and Alanine conformers are prepared via co-crystallization route, with an aim to improve its anticancer effectiveness and to minimize its associated drawbacks. The prepared...

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Bibliographic Details
Main Authors: Farhat Jubeen, Sana Ijaz, Ishrat Jabeen, Usman Aftab, Wajeeha Mehdi, Awais Altaf, Siham A. Alissa, Hanan A. Al-Ghulikah, Safa Ezzine, Imen Bejaoui, Munawar Iqbal
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Arabian Journal of Chemistry
Subjects:
5-Fluorouracil
Co-crystals
Dimers
Molecular docking
MTT analysis
Antitumor efficacy
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535222006153

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http://www.sciencedirect.com/science/article/pii/S1878535222006153

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