Contribution of T Cell Receptor Alpha and Beta CDR3, MHC Typing, V and J Genes to Peptide Binding Prediction

Contribution of T Cell Receptor Alpha and Beta CDR3, MHC Typing, V and J Genes to Peptide Binding Prediction

IntroductionPredicting the binding specificity of T Cell Receptors (TCR) to MHC-peptide complexes (pMHCs) is essential for the development of repertoire-based biomarkers. This affinity may be affected by different components of the TCR, the peptide, and the MHC allele. Historically, the main element...

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Bibliographic Details
Main Authors: Ido Springer, Nili Tickotsky, Yoram Louzoun
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
TCR - T cell receptor
TCR repertoire analysis
peptide binding
epitope specificity
machine learning
deep learning
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.664514/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.664514/full

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