Cholinergic Activation Enhances Resistance to Oral Salmonella Infection by Modulating Innate Immune Defense Mechanisms at the Intestinal Barrier

Cholinergic Activation Enhances Resistance to Oral Salmonella Infection by Modulating Innate Immune Defense Mechanisms at the Intestinal Barrier

Inflammation is a crucial defense mechanism that protects the body from the devastating effects of invading pathogens. However, an unrestrained inflammatory reaction may result in systemic manifestations with dire consequences to the host. The extent of activation of the inflammatory response is tig...

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Bibliographic Details
Main Authors: Ray M. Al-Barazie, Ghada Hassan Bashir, Mohammed M. Qureshi, Yassir A. Mohamed, Ashraf Al-Sbiei, Saeed Tariq, Wim J. Lammers, Basel K. al-Ramadi, Maria J. Fernandez-Cabezudo
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
acetylcholine
cholinergic pathway
Salmonella infection
mucosal innate immunity
antimicrobial peptides
Paneth cells
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00551/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00551/full

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