Incorporation of <i>N7</i>-Platinated Guanines into Thermus Aquaticus (Taq) DNA Polymerase: Atomistic Insights from Molecular Dynamics Simulations

Incorporation of <i>N7</i>-Platinated Guanines into Thermus Aquaticus (Taq) DNA Polymerase: Atomistic Insights from Molecular Dynamics Simulations

In this work, we elucidated some key aspects of the mechanism of action of the cisplatin anticancer drug, <i>cis</i>-[Pt(NH<sub>3</sub>)<sub>2</sub>Cl<sub>2</sub>], involving direct interactions with free nucleotides. A comprehensive in silico molecula...

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Bibliographic Details
Main Authors: Federica De Castro, Giada Ciardullo, Francesco Paolo Fanizzi, Mario Prejanò, Michele Benedetti, Tiziana Marino
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Molecular Sciences
Subjects:
nucleoside analogues
platinum compounds
coordination compounds
cisplatin
antitumor drugs
antiviral drugs
Online Access:https://www.mdpi.com/1422-0067/24/12/9849

Internet

https://www.mdpi.com/1422-0067/24/12/9849

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