Eupatolide, isolated from Liriodendron tulipifera, sensitizes TNF-mediated dual modes of apoptosis and necroptosis by disrupting RIPK1 ubiquitination

Eupatolide, isolated from Liriodendron tulipifera, sensitizes TNF-mediated dual modes of apoptosis and necroptosis by disrupting RIPK1 ubiquitination

Ubiquitination of RIPK1 plays an essential role in the recruitment of the IKK complex, an upstream component of pro-survival NF-κB. It also limits TNF-induced programmed cell death by inhibiting the spatial transition from TNFR1-associated complex-I to RIPK1-dependent death-inducing complex-II or ne...

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Bibliographic Details
Main Authors: Kyeong Ah Park, Chan Seok Jung, Kyung-Cheol Sohn, Eunjin Ju, Sanghee Shin, InWha Park, MinKyun Na, Gang Min Hur
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Heliyon
Subjects:
RIPK1 ubiquitination
Cytotoxic potential of RIPK1
TNFR1 ligation
NF-κB
Eupatolide
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024041239

Internet

http://www.sciencedirect.com/science/article/pii/S2405844024041239

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