Pentagalloyl Glucose-Targeted Inhibition of P-Glycoprotein and Re-Sensitization of Multidrug-Resistant Leukemic Cells (K562/ADR) to Doxorubicin: In Silico and Functional Studies

Pentagalloyl Glucose-Targeted Inhibition of P-Glycoprotein and Re-Sensitization of Multidrug-Resistant Leukemic Cells (K562/ADR) to Doxorubicin: In Silico and Functional Studies

Combining phytochemicals with chemotherapeutic drugs has demonstrated the potential to surmount drug resistance. In this paper, we explore the efficacy of pentagalloyl glucose (PGG) in modulating P-gp and reversing multidrug resistance (MDR) in drug-resistant leukemic cells (K562/ADR). The cytotoxic...

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Bibliographic Details
Main Authors: Nathupakorn Dechsupa, Nopawit Khamto, Pornthip Chawapun, Sadanon Siriphong, Phattarawadee Innuan, Authaphinya Suwan, Thitiworada Luangsuep, Nichakorn Photilimthana, Witchayaporn Maita, Rossarin Thanacharttanatchaya, Padchanee Sangthong, Puttinan Meepowpan, Chatchanok Udomtanakunchai, Jiraporn Kantapan
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Pharmaceuticals
Subjects:
pentagalloyl glucose
P-glycoprotein
drug resistance
PGG
sensitizer
doxorubicin
Online Access:https://www.mdpi.com/1424-8247/16/9/1192

Internet

https://www.mdpi.com/1424-8247/16/9/1192

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