Increased Expression of the Δ133p53β Isoform Enhances Brain Metastasis

Increased Expression of the Δ133p53β Isoform Enhances Brain Metastasis

The Δ133p53β isoform is increased in many primary tumors and has many tumor-promoting properties that contribute to increased proliferation, migration and inflammation. Here we investigated whether Δ133p53β contributed to some of the most aggressive tumors that had metastasized to the brain. <i&g...

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Bibliographic Details
Main Authors: Alexandra N. Boix De Jesus, Ahmad Taha, David Wang, Paulomi M. Mehta, Sunali Mehta, Ashley Reily-Bell, Sasini Polwatta Lekamlage, Adriana Machado Saraiva, Tahmeed Tahmeedzaman, Fouzia Ziad, Ziad Thotathil, Peter Y. C. Gan, Janice Royds, Antony Braithwaite, Noelyn Hung, Tania L. Slatter
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
p53 isoform
Δ133p53β
brain
metastasis
time to metastasis
receptor recycling
Online Access:https://www.mdpi.com/1422-0067/24/2/1267

Internet

https://www.mdpi.com/1422-0067/24/2/1267

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