Natural Polyphenols—Resveratrol, Quercetin, Magnolol, and β-Catechin—Block Certain Aspects of Heroin Addiction and Modulate Striatal IL-6 and TNF-α

Natural Polyphenols—Resveratrol, Quercetin, Magnolol, and β-Catechin—Block Certain Aspects of Heroin Addiction and Modulate Striatal IL-6 and TNF-α

We have examined the effects of four different polyphenols in attenuating heroin addiction using a conditioned place preference (CPP) paradigm. Adult male Sprague Dawley rats received heroin (alternating with saline) in escalating doses starting from 10 mg/kg, i.p. up to 80 mg/kg/d for 14 consecutiv...

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Bibliographic Details
Main Authors: Shaimaa ElShebiney, Rania Elgohary, Marwa El-Shamarka, Noha Mowaad, Osama A. Abulseoud
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Toxics
Subjects:
heroin
conditioned place preference (CPP)
naloxone precipitated withdrawal
polyphenols
resveratrol
magnolol
Online Access:https://www.mdpi.com/2305-6304/11/4/379

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https://www.mdpi.com/2305-6304/11/4/379

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