A systematic approach for evaluating the role of surface-exposed loops in trypsin-like serine proteases applied to the 170 loop in coagulation factor VIIa

A systematic approach for evaluating the role of surface-exposed loops in trypsin-like serine proteases applied to the 170 loop in coagulation factor VIIa

Abstract Proteases play a major role in many vital physiological processes. Trypsin-like serine proteases (TLPs), in particular, are paramount in proteolytic cascade systems such as blood coagulation and complement activation. The structural topology of TLPs is highly conserved, with the trypsin fol...

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Bibliographic Details
Main Authors: Anders B. Sorensen, Per Jr. Greisen, Jesper J. Madsen, Jacob Lund, Gorm Andersen, Pernille G. Wulff-Larsen, Anette A. Pedersen, Prafull S. Gandhi, Michael T. Overgaard, Henrik Østergaard, Ole H. Olsen
Format: Article
Language:English
Published: Nature Portfolio 2022-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-07620-7

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https://doi.org/10.1038/s41598-022-07620-7

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