AtomNet-Aided OTUD7B Inhibitor Discovery and Validation

AtomNet-Aided OTUD7B Inhibitor Discovery and Validation

Protein deubiquitinases play critical pathophysiological roles in cancer. Among all deubiquitinases, an oncogenic function for OTUD7B has been established in genetic NSCLC murine models. However, few deubiquitinase inhibitors have been developed due to technical challenges. Here, we report a putativ...

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Bibliographic Details
Main Authors: Jianfeng Chen, Derek L. Bolhuis, Christian Laggner, Deyu Kong, Le Yu, Xiaodong Wang, Michael J. Emanuele, Nicholas G. Brown, Pengda Liu
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Cancers
Subjects:
OTUD7B
small molecule inhibitor
NSCLC
leukemia
cell proliferation
Online Access:https://www.mdpi.com/2072-6694/15/2/517

Internet

https://www.mdpi.com/2072-6694/15/2/517

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