Golgi localized β1-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLCε to regulate cardiac hypertrophy

Golgi localized β1-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLCε to regulate cardiac hypertrophy

Increased adrenergic tone resulting from cardiovascular stress leads to development of heart failure, in part, through chronic stimulation of β1 adrenergic receptors (βARs) on cardiac myocytes. Blocking these receptors is part of the basis for β-blocker therapy for heart failure. Recent data demonst...

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Bibliographic Details
Main Authors: Craig A Nash, Wenhui Wei, Roshanak Irannejad, Alan V Smrcka
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-08-01
Series:eLife
Subjects:
adrenergic antagonists
GPCR
Golgi
phospholipase C
hypertrophy
Online Access:https://elifesciences.org/articles/48167

Internet

https://elifesciences.org/articles/48167

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