Stereoselective Analysis of the Antiseizure Activity of Fenfluramine and Norfenfluramine in Mice: Is <i>l</i>-Norfenfluramine a Better Follow-Up Compound to Racemic-Fenfluramine?

Stereoselective Analysis of the Antiseizure Activity of Fenfluramine and Norfenfluramine in Mice: Is <i>l</i>-Norfenfluramine a Better Follow-Up Compound to Racemic-Fenfluramine?

The aim of this study was to investigate the comparative antiseizure activity of the <i>l</i>-enantiomers of <i>d</i>,<i>l</i>-fenfluramine and <i>d</i>,<i>l</i>-norfenfluramine and to evaluate the relationship between their concentration i...

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Bibliographic Details
Main Authors: Natalia Erenburg, Emilio Perucca, Jeff Bechard, Celine Dube, Nina Weishaupt, Robin Sherrington, Meir Bialer
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
fenfluramine
norfenfluramine
enantioselectivity
chiral switch
anticonvulsant activity
pharmacokinetic-pharmacodynamic correlation
Online Access:https://www.mdpi.com/1422-0067/25/5/2522

Internet

https://www.mdpi.com/1422-0067/25/5/2522

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