Dissecting the role of the NADPH oxidase NOX4 in TGF-beta signaling in hepatocellular carcinoma

Dissecting the role of the NADPH oxidase NOX4 in TGF-beta signaling in hepatocellular carcinoma

The NADPH oxidase NOX4 has been proposed as necessary for the apoptosis induced by the Transforming Growth Factor-beta (TGF-β) in hepatocytes and hepatocellular carcinoma (HCC) cells. However, whether NOX4 is required for TGF-β-induced canonical (SMADs) or non-canonical signals is not fully understo...

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Bibliographic Details
Main Authors: Rut Espinosa-Sotelo, Noel P. Fusté, Irene Peñuelas-Haro, Ania Alay, Gabriel Pons, Xènia Almodóvar, Júlia Albaladejo, Ismael Sánchez-Vera, Ricard Bonilla-Amadeo, Francesco Dituri, Grazia Serino, Emilio Ramos, Teresa Serrano, Mariona Calvo, María Luz Martínez-Chantar, Gianluigi Giannelli, Esther Bertran, Isabel Fabregat
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Redox Biology
Subjects:
NADPH oxidase
NOX4
TGF-Beta
Hepatocellular carcinoma
HCC
Liver cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723002197

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http://www.sciencedirect.com/science/article/pii/S2213231723002197

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