Shear stress induces autophagy in Schlemm’s canal cells via primary cilia-mediated SMAD2/3 signaling pathway

Shear stress induces autophagy in Schlemm’s canal cells via primary cilia-mediated SMAD2/3 signaling pathway

The Schlemm’s canal (SC) is a circular, lymphatic-like vessel located at the limbus of the eye that participates in the regulation of aqueous humor drainage to control intraocular pressure (IOP). Circumferential flow of aqueous humor within the SC lumen generates shear stress, which regulates SC cel...

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Bibliographic Details
Main Authors: Myoung Sup Shim, Angela Dixon, April Nettesheim, Kristin M. Perkumas, W. Daniel Stamer, Yang Sun, Paloma B. Liton
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Autophagy Reports
Subjects:
autophagy
glaucoma
primary cilia
schlemm’s canal
shear stress
smad2/3
mtor
Online Access:http://dx.doi.org/10.1080/27694127.2023.2236519

Internet

http://dx.doi.org/10.1080/27694127.2023.2236519

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