Shear stress induces autophagy in Schlemm’s canal cells via primary cilia-mediated SMAD2/3 signaling pathway
The Schlemm’s canal (SC) is a circular, lymphatic-like vessel located at the limbus of the eye that participates in the regulation of aqueous humor drainage to control intraocular pressure (IOP). Circumferential flow of aqueous humor within the SC lumen generates shear stress, which regulates SC cel...
Main Authors: | Myoung Sup Shim, Angela Dixon, April Nettesheim, Kristin M. Perkumas, W. Daniel Stamer, Yang Sun, Paloma B. Liton |
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Format: | Article |
Language: | English |
Published: |
Taylor & Francis Group
2023-12-01
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Series: | Autophagy Reports |
Subjects: | |
Online Access: | http://dx.doi.org/10.1080/27694127.2023.2236519 |
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