The efficiency of insulin production and its content in insulin-expressing model β-cells correlate with their Zn2+ levels
Insulin is produced and stored inside the pancreatic β-cell secretory granules, where it is assumed to form Zn2+-stabilized oligomers. However, the actual storage forms of this hormone and the impact of zinc ions on insulin production in vivo are not known. Our initial X-ray fluorescence experiment...
Main Authors: | , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
The Royal Society
2020-10-01
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Series: | Open Biology |
Subjects: | |
Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.200137 |