The efficiency of insulin production and its content in insulin-expressing model β-cells correlate with their Zn2+ levels

The efficiency of insulin production and its content in insulin-expressing model β-cells correlate with their Zn2+ levels

Insulin is produced and stored inside the pancreatic β-cell secretory granules, where it is assumed to form Zn2+-stabilized oligomers. However, the actual storage forms of this hormone and the impact of zinc ions on insulin production in vivo are not known. Our initial X-ray fluorescence experiment...

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Bibliographic Details
Main Authors: Petra Dzianová, Seiya Asai, Martina Chrudinová, Lucie Kosinová, Pavlo Potalitsyn, Pavel Šácha, Romana Hadravová, Irena Selicharová, Jan Kříž, Johan P. Turkenburg, Andrzej Marek Brzozowski, Jiří Jiráček, Lenka Žáková
Format: Article
Language:English
Published: The Royal Society 2020-10-01
Series:Open Biology
Subjects:
β-cells
insulin
pancreatic islets
proinsulin
zinc ions
znt8
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.200137

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