A novel mouse model for investigating α-synuclein aggregates in oligodendrocytes: implications for the glial cytoplasmic inclusions in multiple system atrophy

A novel mouse model for investigating α-synuclein aggregates in oligodendrocytes: implications for the glial cytoplasmic inclusions in multiple system atrophy

Abstract The aggregated alpha-synuclein (αsyn) in oligodendrocytes (OLGs) is one of the pathological hallmarks in multiple system atrophy (MSA). We have previously reported that αsyn accumulates not only in neurons but also in OLGs long after the administration of αsyn preformed fibrils (PFFs) in mi...

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Bibliographic Details
Main Authors: Tomoyuki Ishimoto, Miki Oono, Seiji Kaji, Takashi Ayaki, Katsuya Nishida, Itaru Funakawa, Takakuni Maki, Shu-ichi Matsuzawa, Ryosuke Takahashi, Hodaka Yamakado
Format: Article
Language:English
Published: BMC 2024-05-01
Series:Molecular Brain
Subjects:
Multiple system atrophy
MSA
α-synuclein
Glial cytoplasmic inclusions
GCI
Mouse model
Online Access:https://doi.org/10.1186/s13041-024-01104-7

Internet

https://doi.org/10.1186/s13041-024-01104-7

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