Are morbidity and mortality estimates from randomized controlled trials externally valid? A comparison of outcomes among infants enrolled into an RCT or a cohort study in Botswana

Are morbidity and mortality estimates from randomized controlled trials externally valid? A comparison of outcomes among infants enrolled into an RCT or a cohort study in Botswana

Abstract Background The external validity of the randomized controlled trial (RCT) refers to the extent to which the results of the RCT apply to the relevant, non-trial population and is impacted by its eligibility criteria, its organization, and its delivery of the intervention. Here, we compared t...

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Bibliographic Details
Main Authors: Neil Thivalapill, Shahin Lockman, Kathleen Powis, Rebecca Zash, Jean Leidner, Gbolahan Ajibola, Mompati Mmalane, Joseph Makhema, Roger L. Shapiro
Format: Article
Language:English
Published: BMC 2021-10-01
Series:BMC Medical Research Methodology
Subjects:
External validity; Clinical trials; Implementation science; HIV-Exposed Uninfected (HEU); Pragmatic trials; Treatment effects
Online Access:https://doi.org/10.1186/s12874-021-01343-5

Internet

https://doi.org/10.1186/s12874-021-01343-5

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