Berberine inhibits breast carcinoma proliferation and metastasis under hypoxic microenvironment involving gut microbiota and endogenous metabolites

Berberine inhibits breast carcinoma proliferation and metastasis under hypoxic microenvironment involving gut microbiota and endogenous metabolites

A potential role of berberine, a benzyl isoquinoline alkaloid, in cancer therapy is apparent. Its underlying mechanisms of berberine against breast carcinoma under hypoxia have not been elucidated. We focused on the doubt how berberine restrains breast carcinoma under hypoxia in vitro and in vivo. A...

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Bibliographic Details
Main Authors: Yanfang Sun, QianQian Zhou, Fangming Chen, Xiaoyan Gao, Linjun Yang, Xiaoyan Jin, Michael Wink, Farukh S. Sharopov, Gautam Sethi
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Pharmacological Research
Subjects:
Berberine
Breast carcinoma
Hypoxia-inducible factor-l alpha (HIF-1α)
Gut microbiota
Plasma endogenous metabolites
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661823001731

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http://www.sciencedirect.com/science/article/pii/S1043661823001731

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