An in vitro CRISPR screen of cell-free DNA identifies apoptosis as the primary mediator of cell-free DNA release

An in vitro CRISPR screen of cell-free DNA identifies apoptosis as the primary mediator of cell-free DNA release

Abtract Clinical circulating cell-free DNA (cfDNA) testing is now routine, however test accuracy remains limited. By understanding the life-cycle of cfDNA, we might identify opportunities to increase test performance. Here, we profile cfDNA release across a 24-cell line panel and utilize a cell-free...

Full description

Bibliographic Details
Main Authors: Brad. A. Davidson, Adam X. Miranda, Sarah C. Reed, Riley E. Bergman, Justin D. J. Kemp, Anvith P. Reddy, Morgan V. Pantone, Ethan K. Fox, R. Dixon Dorand, Paula J. Hurley, Sarah Croessmann, Ben Ho Park
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-06129-1

Internet

https://doi.org/10.1038/s42003-024-06129-1

Similar Items