Ferritin Conjugates With Multiple Clickable Amino Acids Encoded by C-Terminal Engineered Pyrrolysyl-tRNA Synthetase

Ferritin Conjugates With Multiple Clickable Amino Acids Encoded by C-Terminal Engineered Pyrrolysyl-tRNA Synthetase

This study reports the application of expanding genetic codes in developing protein cage-based delivery systems. The evolved Methanosarcina mazei pyrrolysyl-tRNA synthetase (PylRS)•tRNAPyl pairs derived from directed evolution are examined to probe their recognition for para-substituted phenylalanin...

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Bibliographic Details
Main Authors: Yi-Hui Wang, Mu-Lung Jian, Pei-Jung Chen, Jo-Chu Tsou, Le P. Truong, Yane-Shih Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Chemistry
Subjects:
pyrrolysyl-tRNA synthetase
ferritin-drug conjugates
strain-promoted azide-alkyne cycloaddition
p-Azido-l-phenylalanine
amber suppression efficiency
drug delivery
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2021.779976/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2021.779976/full

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