HPV-16 E7 Interacts with the Endocytic Machinery via the AP2 Adaptor μ2 Subunit

HPV-16 E7 Interacts with the Endocytic Machinery via the AP2 Adaptor μ2 Subunit

ABSTRACT Human papillomavirus (HPV) E7 plays a major role in HPV-induced malignancy, perturbing cell cycle regulation, and driving cell proliferation. Major targets of cancer-causing HPV E7 proteins are the pRB family of tumor suppressors, which E7 targets for proteasome-mediated degradation and who...

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Bibliographic Details
Main Authors: Om Basukala, Oscar Trejo-Cerro, Michael P. Myers, David Pim, Paola Massimi, Miranda Thomas, Corrado Guarnaccia, David Owen, Lawrence Banks
Format: Article
Language:English
Published: American Society for Microbiology 2022-12-01
Series:mBio
Subjects:
HPV
E7
endocytosis
clathrin
AP2
Online Access:https://journals.asm.org/doi/10.1128/mbio.02302-22

Internet

https://journals.asm.org/doi/10.1128/mbio.02302-22

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