Inhibition of macrophage migration inhibitory factor (MIF) suppresses apoptosis signal-regulating kinase 1 to protect against liver ischemia/reperfusion injury

Inhibition of macrophage migration inhibitory factor (MIF) suppresses apoptosis signal-regulating kinase 1 to protect against liver ischemia/reperfusion injury

Background: Hepatic ischemia–reperfusion (I/R) injury is a major complication leading to surgical failures in liver resection, transplantation, and hemorrhagic shock. The role of cytokine macrophage migration inhibitory factor (MIF) in hepatic I/R injury is unclear.Methods: We examined changes of MI...

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Bibliographic Details
Main Authors: Sanyang Chen, Qiwen Yu, Yaodong Song, Zongchao Cui, Mengke Li, Chaopeng Mei, Huning Cui, Shengli Cao, Changju Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
MIF deficiency protects from hepatic I/R injury hepatic ischemia-reperfusion injury
macrophage migration inhibitory factor
apoptosis signal-regulating kinase 1
inflammation
apoptosis
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.951906/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.951906/full

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