ADAM17 knockdown mitigates while ADAM17 overexpression aggravates cardiac fibrosis and dysfunction via regulating ACE2 shedding and myofibroblast transformation

ADAM17 knockdown mitigates while ADAM17 overexpression aggravates cardiac fibrosis and dysfunction via regulating ACE2 shedding and myofibroblast transformation

A disintegrin and metalloprotease domain family protein 17 (ADAM17) is a new member of renin-angiotensin system (RAS) but its role in the pathogenesis of diabetic cardiomyopathy (DCM) is obscure. To test the hypothesis that ADAM17 knockdown mitigates while ADAM17 overexpression aggravates cardiac fi...

Full description

Bibliographic Details
Main Authors: Jing Cheng, Fei Xue, Cheng Cheng, Wenhai Sui, Meng Zhang, Lei Qiao, Jing Ma, Xiaoping Ji, Wenqiang Chen, Xiao Yu, Bo Xi, Feng Xu, Guohai Su, Yuxia Zhao, Panpan Hao, Yun Zhang, Cheng Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Pharmacology
Subjects:
ADAM17
cardiac fibrosis
ACE2
myofibroblast transformation
TGF-β1/Smad3 signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.997916/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.997916/full

Similar Items