Amyloid-like aggregates of the yeast prion protein ure2 enter vertebrate cells by specific endocytotic pathways and induce apoptosis.

Amyloid-like aggregates of the yeast prion protein ure2 enter vertebrate cells by specific endocytotic pathways and induce apoptosis.

BACKGROUND: A number of amyloid diseases involve deposition of extracellular protein aggregates, which are implicated in mechanisms of cell damage and death. However, the mechanisms involved remain poorly understood. METHODOLOGY/PRINCIPAL FINDINGS: Here we use the yeast prion protein Ure2 as a gener...

Full description

Bibliographic Details
Main Authors: Chen Zhang, Antony P Jackson, Zai-Rong Zhang, Yan Han, Shun Yu, Rong-Qiao He, Sarah Perrett
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2932714?pdf=render

Internet

http://europepmc.org/articles/PMC2932714?pdf=render

Similar Items