A novel patient-derived meningioma spheroid model as a tool to study and treat epithelial-to-mesenchymal transition (EMT) in meningiomas

A novel patient-derived meningioma spheroid model as a tool to study and treat epithelial-to-mesenchymal transition (EMT) in meningiomas

Abstract Meningiomas are the most common intracranial brain tumours. These tumours are heterogeneous and encompass a wide spectrum of clinical aggressivity. Treatment options are limited to surgery and radiotherapy and have a risk of post-operative morbidities and radiation neurotoxicity, reflecting...

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Bibliographic Details
Main Authors: Laurien L. van de Weijer, Emanuela Ercolano, Ting Zhang, Maryam Shah, Matthew C. Banton, Juri Na, Claire L. Adams, David Hilton, Kathreena M. Kurian, C. Oliver Hanemann
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Acta Neuropathologica Communications
Subjects:
Meningioma
Spheroids
EMT
MERTK
HDAC
Combination therapy
Online Access:https://doi.org/10.1186/s40478-023-01677-9

Internet

https://doi.org/10.1186/s40478-023-01677-9

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