Dramatic secukinumab-mediated improvements in refractory leprosy-related neuritis via the modulation of T helper 1 (Th1) and T helper 17 (Th17) immune pathways

Dramatic secukinumab-mediated improvements in refractory leprosy-related neuritis via the modulation of T helper 1 (Th1) and T helper 17 (Th17) immune pathways

Abstract A 39-year-old woman was diagnosed with relapsed multibacillary leprosy and refractory neuritis. Here, we describe an evident loss of therapeutic effectiveness after the third pulse of corticosteroids, which may be attributed to tachyphylaxis and the posterior modulation of interferon- γ (IF...

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Bibliographic Details
Main Authors: Patrícia Shu Kurizky, Jorgeth de Oliveira Carneiro da Motta, Natanael Victor Furtunato Bezerra, Marcia Carolline dos Santos Sousa, Danilo Corazza, Taiana Karla dos Santos Borges, Ciro Martins Gomes
Format: Article
Language:English
Published: Sociedade Brasileira de Medicina Tropical (SBMT) 2021-12-01
Series:Revista da Sociedade Brasileira de Medicina Tropical
Subjects:
Leprosy
Interleukin-17
Neuritis
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822021000100728&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822021000100728&tlng=en

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